Quote Originally Posted by asplundii View Post
Considering the spider is probably the most outcrossed morph out there if it was possible to break "wooble" from the pattern phenotype then we ought to have seen it by now. I am betting it is one and the same gene and we will not see them separated.
And yet I've been told first hand by the people that have bred more spider combos than any one that they have seen normal spider sibs that wobble.



Ummm, no. The spider gene has a dominant effect over the WT gene so you can not "replace" it by breeding to another morph any more than you can replace it by breeding to a WT. Unless you somehow get a gene duplication event in your breeding you will have a mutant copy and a WT copy of the gene and the mutant copy is the dominant acting source of the "wobble". And duplication events rarely, if ever, copy single genes but instead copy whole blocks of genes which is more likely to cause genetic carnage...
I never said replace it I was implying strengthening the gene by adding in something genetically that its lacking that causes the wobble.
Then if this is 100% true and the spider gene is the only reason for wobbling then it puts to rest the idea that there are spiders that don't wobble.

Again, no. If breeding to "morphs" in general is the cure then you ought to see it happen breeding to a WT. I refuse to believe that every morph out there has this magical curative effect and that WT ball do not have it. It is just bogus.
Again I never said every morph has some curative effect I never said that any morph had a curative effect. But you can't deny that there are things in the gene's of these animals that we don't understand. So to say that it isn't out there also isn't true.

No. Supplement therapy does not "cure" the mutant gene, it is still there and still exerts its effect in the absence of the supplement. And in gene replacement therapy you are adding in an exogenous functional copy of a defective gene. And it does not actually replace the defective gene, it inserts, via viral means, randomly into the chromosome and functions from those sites. Additionally, in those cases where it is implemented it is with recessive genes where a single WT copy of the gene can exert an effect. It has not been done to correct dominant type defects, which is what the spider mutation is.
So your saying that by adding addition working copy's of genetic code in to the DNA of the animal the defective gene can be corrected, not eliminated but corrected in that individual?