A spider ball python could not exist in the wild. They would soon die off because of their inability to feed, they simply couldn't consistently enough hit a rat on their first strike to survive.
But we are in controlled environments, with a keeper holding a thawed rat steady a spider can survive in captivity fine, we don't know if they live an ideal life or if they're constantly tormented by it but yet we continue to breed them. WE make them
As long as you are selling animals for what they are and informing buyers of everything I don't see a problem with hybrids, why not experiment and try new things? Why can't we play 'God'