Now, I don't really have any experience with RIs...but I do have a female who hisses at me when she's handled and shortly after. The sound is pretty soft and can sound like wheezing Could it be that what you are hearing is a small hiss and not actually a wheeze? I only say this because if his lungs are clear, he shouldn't be "wheezing" because wheezing indicates lung obstruction by mucus. Here's a video of wheezing in humans (yes, I realize that this is a snake and not a person...but it's pretty good about demonstrating what wheezing sounds like): http://www.stethographics.com/main/p...ls_wheeze.html Here's a video of a ball python hissing (I do NOT condone people doing this to their snakes while in shed...but it does demonstrate the sound): https://www.youtube.com/watch?v=2WBz7tQVYZ4

See if you can get a video or audio recording of the sound. That might help some people with a diagnosis.