I used reptile relief for 2-3 years because it was the only thing I could buy locally. The bottle said to spray once ever 3 days and you could use it on the reptile as long as it wasn't running off. Well......every three days leaves you with still having a mite problem. I had to use it once a day for almost 7 days before it would totally get rid of mites. I ordered some PAM, was given a female breeder that had mites, before putting her in QT I sprayed the tub with the PAM. Waited til the next morning and took her from the bag put her in tub.....well no more mites with only 1 treatment!!! It's way worth the 27$ I paid in total for it. I mean come on guys, whats the health of your animals worth to you? I'm not a big time breeder and most of mine are family pets so they are worth alot more to me than just wait money I've put into them.