I agree with the handling issue, but also you have to handle when cleaning their home and I like to get mine to the Vet asap after arriving which calls for some handling. I think getting the Vet out of the way right of the bat gets the majority of the stress out of the way right off the bat. Other than these kinds of handlings I like to leave them alone. I feel sorry for one of our girls as she came in with a minor case of an RI (Due to Fed-ex screwing up. ) and we have to give her an anti-biotic everyday for 10 days. I'm sure just the method you have to use to administer the anti-biotic is stressful on her (heck it is stressful on us! ), but ultimately it is in her best interest. We just won't worry to much about not eating as soon as our others did since it will be a longer time period for her to adapt, but she is a gorgeous girl and I hope our double het for VPI Snow finds her sexy when the time comes in a couple months.