Reading the animals well, & planning every move (never making dumb ones- like snakes encircling your neck, lol) is a big part of it, yes. Using the safest methods whenever there's an option.
And I agree that "tags" are avoidable- I never got bit working with hots. It means being focused, & never working w/ them when tired, distracted*, feeling poorly, or anything less than 100% sober, & not under any "influence" legal or otherwise. (*distracted includes showing off, having too much going on around you, etc)
But so is not working giant snakes alone- over-estimating your own KSA's. For example, keepers have gotten in trouble being alone when opening an enclosure to feed. Or I remember some years back, one guy was found (dead- constricted) in the outbuilding with one of his large snakes he'd been trying to medicate for something- the snake "objected" & he had no one else there with him. I think it's safe to say that arachnids don't have the physical power that giant snakes do- therein lies the big (pardon the pun) difference.