It shouldn't be a problem. I have 2 ball pythons in my bedroom. I'll agree it definitely depends on your ability to sleep, your substrate, and your snake itself. Mine's on a quiet substrate so I don't hear them slithering at night. One I don't even hear at all. My other one... Well he's very active and likes to climb so you hear the occasional thump as he's climbing. I try to do a nice long handling secession before bed and that usually calms him down.

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