Sorry for your difficulties with this guy. I sorta doubt it would be IBD (& I have zero personal experience with it but) just based on the common knowledge that it tends to overwhelm pythons rather quickly, & you've had him for quite a while in terms of the timeline I've read that other affected pythons suffered. It's obvious that he has "some" kind of health issue, but you'll need more tests- & to play "detective" to get to the bottom of it. You've got guts for taking this guy on, I'll say that. I hope you get some good answers soon & that there's a "fix" for what ails him.
Also, a w/c & imported snake will have been exposed to a great many things, & the stress puts them at higher risk for their immune system to be unable to fend off whatever it is. And it could be more than one thing too- as you already know- he has hookworms + some sort of infection. But at least you're not seeing neuro symptoms, right? So I doubt it's IBD, & let's hope whatever it is, it responds to treatment.
I'd also worry about things like cryptosporidiosis. Here's a link for that: https://www.addl.purdue.edu/newslett...r/snakes.shtml
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