I've had issues with different brands of Pine Bedding (increased mortality--about 1% of the population dies/week). If you notice your rats/mice start sneezing as soon as you clean their cages: then you might have an issue.
Tractor Supply Pine Flake (8 cu. ft/$6) seems to work fine for me: I open the bag and dump the shaving into a plastic bin the week before I use them and let them 'air out'. No issues. Saves a lot of money in the long-run vs. Aspen.
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