Florence hissed at me

[Bogertophis]

Your relationship with her has suffered no lasting damage, not to worry. As already mentioned ^^^ she may be going into shed, or just wanted some alone
time. Snakes aren't terribly social anyway...it's likely your approach was just too abrupt this time, expecting her to be in the same mood as when you last
held her. You haven't had her that long, & even if you had, it's always better to re-introduce yourself slowly to a snake each time that you approach.

The BCI I had for many years was like that...loved to be out, chilling with me ("watching" a movie for a couple hours, & not wanting to go back in her cage),
but every once in a while (& NOT related to being in shed) she would hiss up a storm when I approached her. I never rushed her...I touched her (not near
her face...just on her body) gently while she "remembered" that she knew me...she never turned to bite either, she just gradually stopped hissing and then I'd
pick her up & take her out...& she was fine. She never bit me even once, but she was a feisty biter when she was given to me as a yearling (she had changed
hands several times because of that before coming to me). I knew she was just terrified...snakes are shy, & they mostly bite out of fear and self-defense, that
or honest feeding mistakes.

I also don't think that if a snake hisses at you & you decide to leave them alone & NOT push it, that they somehow learn to manipulate you this way. If you take
your time & really empathize, snakes seem to know. If you say "never mind" & try another day, all is forgotten & their mood will likely be back to "normal"....so
don't stress over it. Remember that snakes do NOT recognize us visually...use your scent & touch to jog their memory of who you are, trust me on this. This is
why many keepers use "hook training" (touch recognition)...so their hands aren't within reach by the snake, but it's the same idea.