a 4ft enclosure is plenty for even the biggest beeps, male or female. i don't think i'd be comfortable with anything smaller than 4ft for a female; a male you can probably get away with something a tad smaller, but IMO if you can go bigger, go bigger.
i try to handle everyone at least once or twice a week. some handle it better than others; my CG girl (link to her progression thread) does not like to be handled. she is not defensive or aggressive in any way, nor does she hiss, but her body language says it all. what's important is that you start handling with short sessions, like 5min. twice a week and allow the snake to learn that you're not a threat when you go and pick them up. they'll learn and start to relax around you. you can increase the length of the handling sessions as you both progress and you get better at reading snake body language, but don't handle them for more than like 20min. as that's just not what they want to do lol. my eldest boy is a sweetheart and i could handle him all day if he let me, but it's not about me.![]()