With this annoying cold snap attacking most of North America, heaters are going to sap humidity like mad. Your best bet is to mist twice a day but make sure between misting that the sides of the tank are drying out.
Your absolute best location for humidity gauges are a few inches above the surface of the substrate. This allows you to gauge the ambient air humidity and not just the surface of the substrate which may be slightly damp and thus give you a false sense of humid environment.
On the subject of substrate, it is fine to lightly mist the substrate but it needs to dry out between misting. If you notice the walls of the tank or the substrate itself is still damp when you go to mist then hold off until the next time to mist.
Because of how dry heaters can make houses, it might get sub 20% humidity in your house which is going to make keeping a glass tank even harder to control. I would resign yourself to trying to shoot for 50% humidity. If the snake is going into shed you can then be more liberal with misting and even think on adding a humid hide.
One other long term solution in the winter is to get a humidifier for the room the snakes are in. It will help normalize the ambient humidity in the room thus making it less of an uphill battle against these dry winter months.