other than birthing, reproductive and neurological issues, ball python morphs do not affect anything but their looks.
the Desert gene female cannot reproduce and she will either not produce viable eggs, or die while passing eggs.
the Spider gene comes with a neurological affliction that causes their famous wobble.
some genes, when crossed, produce babies that are inviable or are more prone to life-threatening defects, such as Super Spider (lethal), Caramel Albino (kinking), or Champagne x Spider pairing (lethal).
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