Well considering woma/balls already exist, it seems some people made it happen without issue. here a thread with a picture of one https://ball-pythons.net/forums/show...n-hybrid-cross
from what ive been told, any python theoretically should be able to breed with any python and any boa theoretically should be able to breed with any boa. However I doubt we will see any sand boa anaconda hybrids any time soon and it might be a challenge getting a ball and a gtp to breed. So physical limitation can still apply.