Well, the only problem would be the temps.
Bloods actually like it a bit cooler then Ball Pythons. My cool end is only about 74 to 77 and the warm end up to 84/85 or so. If kept to warm, they can get grouchy. They do need humidity, but not a "swamp". And they need some air flow, so its not just humid, stagnant air. I really do not find the setup difficult at all. But high ambient heat might be an issue..
You can keep them in smaller tubs just like Ball Pythons, they prefer smaller when they are young. As adults, the males could stay in the same size as adult Ball Python females, but a female blood might end up needing a bigger size.
Many people eventually give them a T8 sized enclosure, 4 feet wide.
You could always keep the Blood in a different "cooler" part of the house![]()