Quote Originally Posted by Coluber42 View Post

I'm also not really ethically comfortable with the idea breeding for scalelessness. Maybe a scaleless snake can lead a perfectly normal life in captivity. But I can't help but wonder if it's likely to be more sensitive to husbandry issues like the humidity range, scrapes or cuts or injuries from nose/head rubbing in amounts that wouldn't much affect a normal snake, infections, or just overall skin sensitivity to things like moisture, urine, substrates, etc. That's not to say they can't live perfectly decent lives if properly provided for, but if it makes them harder to provide for appropriately, that is not a good thing considering how popular they are as low-maintenance pets.
I can't speak for scaleless ball pythons, but scaleless corn snake are just as hardy as their scaled counterpart, they even did scientific studies and proved that they do not dehydrate or require different humidity ranges, nor are they pron to injury.

They can also live perfectly normal lives in the wild. Wild rat snakes, rattle snakes, hognose, and bull snakes have all been found in the wild as adult animals.