There were reports a few years ago of an abnormally cold winter and iguanas falling out of the trees because they were so cold.
I also read a study of large snakes where they had a split outdoor/indoor enclosure. They knew how to get inside/outside, but had no idea to get inside and stay inside when the temp dropped. The researchers had to bring the snakes indoors each morning because they were to cold to move. So it was proven that they don't know to seek shelter from inclement weather (brumate). I imagine that if they don't die from freezing directly, they will be easy prey to predators, and their immune system will be compromised as well.
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