Your big girl sounds a lot like mineI just want to say that you CAN work with her, so don't give up just yet! Anyway, my girl squirms all over the place when she's out, I just have to make sure I've got a good hold on her and am low to the ground lol. She's also VERY hissy. As in, she hisses when I pick her up, when I open the tub, or just when I walk by. Sometimes she even hisses if I move too quickly when handling her.
With your girl, I'm going to assume the hiss was a warning: if you kept messing with her, she most likely would have struck. This is a new environment for her, so are you sure her temps and humidity are spot on? How many hides does she have? How cluttered is it? She may just need some more security. Also, is she going into shed, or is feeding day coming up? All of these can contribute to a feisty ball
That said, the bites aren't that bad. Trust me, I've been bitten more than my fair share lol. If you're really scared, get a snake hook, or put your hand in a pillow case and pick her up like you would dog poop :p
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