There have actually been quite a few interesting studies on what happens to a pythons heart after eating. Basically the heart just goes nuts, it'll actually increase in size, pumps a lot harder and it's all pretty normal. Scientists are studying it to see if they can get some insight on how human hearts react. Here is some interesting reading material for you.
http://ajpregu.physiology.org/conten....2011.abstract
http://www.globalanimal.org/2011/10/...-hearts/56984/
http://uanews.ua.edu/2011/10/snakes-...ience-article/
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