Anyone's who's ever had a ball python come down with an RI because their temps dipped into the 70s for a couple of days will attest to how unlikely that scenario is.
I've found ball pythons to be quite intolerant of inadequate temperatures, and actually had an escaped snake inadvertently commit suicide years ago, by making her way into a closet against an outer wall. It was poorly insulated, and too cold, and the cold killed her.
Florida's cold snaps would take out ball pythons with a lot more efficiency than they're doing in the Burmese pythons.