With the duramycin 10, you should have the bottles at least half full when you add the powder. If you dump the powder into just a wet bottle, it turns into concrete.

I'm treating any rats with true symptoms with the dual antibiotics and the ones that I think I heard sneeze, etc, with the Duramycin. I lost another adult female today. Most are looking less poorly.

My vet disapproves of "shotgun" treating groups of animals. I prefer treating a colony/herd, but he's pet-oriented. I'd rather treat a healthy rat unneeded, than wait until a sick rat gets sick enough to look terrible, THEN treat it. I wouldn't treat healthy rats just because, but since many only show some sneezing then look fine, while others sneeze then look terrible, I'd rather treat the colony of breeders.