I only handle my snakes once or twice a week maximum because I don't want to stress them out. For the most part - if I am able to get them out without getting bit - then they will settle down if I continue to hold them. The problem I have is their reluctance to even be picked up - I feel bad for making them be picked up when it is clear they do not want it - they will try to scramble away as fast as they can - they must be scared.