As for spiders.. I cant comment on that seeing as im getting a Bee.. But i will not be putting it to another spider or spider morph. I simply would not do that and risk creating snakes with serious problems.. Just my opinion..
Not really going to make a difference unfortunately. All Spiders are at least slightly tweaked. Sometimes it is so subtle that it's hard to notice. You'll have the chance of producing tweaked babies from pairing that bee with anything.