This is the time of year most snakes like to go off feed. Could you describe your husbandry more in full? What is your humidity, substrate, and size of tank?

What are you using for hides? If they are log hides, remove them because half logs are useless to ball pythons. Are the hides tight and secure or does he have a lot of empty space when he's in the hide?

What are you trying to feed him and what is your method of doing so? Frozen or live? What size prey item and what kind?

Add pictures and these questions will be much more easily answered!