There are a few yes, some lines of hypo don't gel with other lines, some axanthic lines are not compatible (TSK and VPI for example) off the top of my head that's about all I can think of. It's certainly never a problem with things like albino, pied, clown and Genetic stripe.


For example if you had two incompatible lines of axanthic (both still axanthic, both genetically reproducable) and bred them together you'd get double-het normals..