Ive had my ball python for about 8 months now. Shes getting to be about 2 1/2-3 feet long. Shes (sex hasn't been confirmed, but shes seems more slender and less bulky) been shedding and eating regularly. She comes out during most nights and does switch between her cool and warm side hides. Up until about a couple weeks ago, she had no issue with me getting her out of her tank and had only hissed at me a couple times during a shed (totally understandable).

However, now whenever I try to pick her up, she hisses and runs away She has never stricken or shows signs of aggression so I thought maybe it could be some kind of stress? She allowed me to pick her up once in the past two weeks or so without having her hiss at me.

She is still eating perfectly fine, Im giving her small rats (weighing around 60g) every 12ish days (sometimes 14), She last ate on Feb. 15th. Her last shed was on Jan. 13th and for the time i've had her, she sheds every two months and I havent noticed a change in her colouring so Im almost 100% sure shes not shedding.

One of my coworkers said she could just be moody because of the seasons changing?? Even if her enclosure temps aren't changing, she might be able to sense it anyways?? I havent had her for a full year yet so this is my first time having her for a winter-spring transition, but I’m just worried that maybe shes not happy with her enclosure? Ive changed nothing since I got her… Please let me know what you think!!!

Tank Details (which basically haven't changed in the 8 months)
3 feet long and 1 1/2 feet deep, glass with front opening doors. It had a mesh top which I covered most of it with aluminum tape to help keep heat/humidity in (except where the heat bulbs are coming down)
Warm side: Temp of 93 during the day and around 88 at night
Cool side: Temp of 77-79 consistently
Humidity: can be anywhere between 30% (overnight usually) and 50% and I mist at least once a day, where it does go up to about 70% when i do so. I have a dry house so the humidity has always been a hassle for me
Substrate: Paper towel