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  1. #1
    Don't Push My Buttons JLC's Avatar
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    A Lesson in Basic Genetics

    Layman’s Crash Course in Ball Python Genetics



    This explanation is not meant to be taken as a scientific study or anything like that. It is written from a layman's point of view in order to offer a basic understanding of how genetics work in Ball Python breeding and the various genetic terms as they are commonly used in the BP community. Hopefully the visuals created for this lesson will provide a solid foundation for future learning.



    GLOSSARY OF TERMS

    Allele – One member of a pair of genes at the same locus.

    Co-Dominant – A visible mutation appears when a single gene at an allele is different than normal. A matched pair of this gene brings about a “super” form that looks different than the single.

    DNA -- Part of the genetic code that makes up all living things.

    Dominant – A visible mutation appears when a single allele at a locus is different than the normal. A matched pair of the mutated alleles will appear the same as the single.

    Gene – A molecular unit of DNA responsible for the physical and inheritable characteristics of an animal.

    Heterozygous (Het) – An unmatched pair of alleles at any given locus…this term is usually reserved for recessive traits that do not show up even though one gene is present.

    Homozygous (Homo) – A matched pair of mutated alleles at any given locus.

    Locus– The location of a gene/allele on the DNA strand.

    Recessive – A matched pair of mutated alleles must be together at the same locus in order to bring about a visible change.




    HOW DOES ALL THIS WORK?

    Picture a pair of shoestrings. Hold them up side-by-side. Now picture them with little matched pairs of colored balls stuck to each of them:







    Each strand represents one of the two DNA strands all animals have.

    Each colored dot represents a single gene or allele.

    Each pair of colored dots represents a pair of genes/alleles located at a specific locus.



    Each pair of genes has a different “job” in determining the look of an animal. It takes many different pairs of genes, each doing a specific job, just to determine the overall pattern and colors of a snake.



    When two animals mate and create young, each parent contributes one copy from their pairs of genes to create a whole new set of pairs in the offspring. For instance, the red dots…one red dot from the mom and one red dot from the dad. Always. One yellow dot from the mom, and one yellow dot from the dad.







    Most of the time, enough of these genes match up in such a way as to create what we call a “normal” or “wild type” appearance. Even within this “normal” range, there are so many different genes at work, and in so many different combinations, that the appearance of the animals will always have some variance…especially in a species like the ball python. There are many different looks that are all considered “normal.” For the purposes of this study, which is meant to lead to an understanding of breeding for various ball python morphs, let’s say that animals are considered “normal” because their specific genetic makeup is not only common, but is also too complicated and unpredictable to reproduce any single trait (such as lots of spots or a lack of spots) with any degree of certainty. Any visible trait that can be consistently and predictably reproduced is called “genetic” and the animals with these specific genetic traits are referred to as “morphs”.



    WHAT MAKES A MORPH?

    Occasionally, a single gene (or gene pair) will mutate outside of the normal variant range. This will cause the animal to look different from its normal peers and they will be called “morphs.” Some examples of this are Albinos, Axanthics, Spiders, and Pastels.



    Different types of gene mutations will behave or affect the animal differently.



    Many morphs are Recessive, which means they must have a matched gene pair in order to make a visual difference in the animal. Albinos, Axanthics, and Piebalds (Pieds) are examples of Recessive morphs.



    And many other morphs are Dominant or Co-dominant, which means you can see a different look with just a single gene being represented.



    What’s the difference between Dominant and Co-dominant?

    A Dominant gene will produce the same look in the animal whether it is a single gene or a matched pair. Spiders and Pinstripes are examples of this type of morph.



    A Co-dominant gene will produce one look when a single mutated gene is present and an entirely different look if there is a matched pair of the mutation. Pastels and Mojaves are examples of this.



    So what happens when I breed XXX to xxx?



    Let’s start with Recessives.







    Notice the genetic chain for our Albino Mom. At one specific locus, instead of the yellow dots that a normal might have, she has a pair of A’s. The Dad is normal, so he just has yellow dots. Each parent contributes one gene from that locus to their offspring, and as you can see, the offspring has one A and one yellow dot. Because the Albino trait is recessive, it won’t show through the yellow dot on the other side and the baby looks normal. But she IS carrying an albino gene. (She is Het Albino.) And she has a 50/50 chance of passing that gene on to her own offspring as well. (Each baby she produces will either get the A or the yellow dot from that locus.) If she is mated to another snake that also carries at least one albino gene, then there is a chance one of their babies will inherit an A on both sides of the “shoe string” and display the bright yellow and white traits of an albino ball python.



    The following graphics show the potential offspring of a Het Albino with another Het Albino, and a Het Albino with an Albino mate.











    What about all those %’s people talk about?



    When dealing with Het x Normal and Het x Het breeding pairs, all the Normal-looking offspring have a chance of being Het, but you can’t tell by looking whether or not it has the mutated gene. In a Het x Normal pairing…each offspring has a 50% chance of carrying the gene, so it is called “50% Het”. In a Het x Het pairing, all normal babies have a 66% chance of carrying the recessive gene and that’s where the “66% Het” term comes from.



    Once one of these Possible Het animals mates with another carrying the same gene and produces visible morph offspring, they are considered “Proven” and are no longer referred to as “possible” or by any percentages. (Except maybe 100%. ;-) )



    People sometimes use the term “100% Het” to refer to an animal that is an offspring of a visible morph because it is 100% certain that one copy of the recessive gene was passed on.



    A Look at Dominant and Co-Dominant



    With the Dominant morphs, it only takes one copy of the mutated gene to create a visual affect. With no known difference for having two copies. (Except that with a true homozygous form of a dominant morph, all the offspring would be guaranteed to carry the trait.)



    Note the “S” represents the mutated gene that gives us the Spider morph, while a normal would have a light blue dot.







    And here, we have the potential offspring of a Spider x Spider pairing. I have used “???” in place of an image for the “Homozygous Spider” because, as of my understanding at this time, no one has offered proof of their existence. Speculation is that a homozygous form would look no different than a spider with a single mutated gene. Therefore, it would be impossible to determine if a spider were “super” until it had produced several clutches of entirely spider offspring. But there is also speculation that when that mutated gene is paired with a matching one, the results are fatal, and therefore, no “super spiders” have survived incubation.







    And now we’ll take a look at Co-Dominant morphs.



    There are many co-dominant morphs, but our example here will be using the “Yellow Belly” and “Ivory” morphs. While the differences from a Normal can be subtle, the Yellow Belly (YB) has distinct characteristics that can be consistently recognized and passed on to offspring. When the snake is carrying a single mutated gene on this particular locus, it is called Yellow Belly or Het Ivory. When both copies of the mutated gene are present, the animal is called an Ivory and has a completely different look from its Het form.



    These next two graphics show what you can get when you mate a YB to a Normal and a YB to another YB. Here, the mutated gene is represented by a Y and the normal gene by a blue dot.











    If you mate a Yellow Belly to an Ivory, all the babies will be either YB or Ivory. And two Ivories will give you all Ivories.



    So how do you know if a morph is Recessive or Dominant or what?



    It’s basically just a learning curve you have to get yourself over. Here are some lists of basic morphs and which category they fall into. It is far from exhaustive.



    RECESSIVE:
    Albino
    Axanthic
    Caramel Albino
    Clown
    Genetic Stripe
    Ghost (Hypo)
    Lavender Albino
    Piebald (Pied)

    DOMINANT:
    Pinstripe
    Spider

    CO-DOMINANT:
    Butter – Blue Eyed Leucistic
    Cinny – Super Cinny
    Enchi – Super Enchi
    Fire Ball – Black Eyed Leucistic
    Lesser – Blue Eyed Leucistic
    Mojave – Blue Eyed Leucistic
    Pastel – Super Pastel
    Yellow Belly – Ivory



    This has been a very basic and simple overview of Ball Python genetics. If one wants to dig deeper, one can begin to look into combo-morphs, where multiple gene pairings are being manipulated. There are also morphs out there being worked with whose genetics are not yet fully understood with “hidden genes” and other mysteries. There are sometimes combinations of morphs that seem to go against these basic rules, such as a Het Axanthic causing a visual difference when combined with a Pastel. There are issues of “compatibility” to be aware of, and different “lines” of morphs. Sometimes the same morph will have different names. There is much to learn and absorb and it should be seen as an exciting challenge to work on for the rest of your life!



    LEARN MORE:

    Markus Jayne's Genetics
    Ralph Davis' Morph Matrix
    NERD's Ball Python Morph Gallery
    BP.net's Morph FAQs
    NextWorldExotic's Hunter's Guide to Morphs
    Punnett Square Calculator

    ____________________
    Authored by JLC of Ball-Pythons.net
    Last edited by JLC; 09-14-2011 at 09:34 AM.

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  3. #2
    Don't Push My Buttons JLC's Avatar
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    Re: A Lesson in Basic Genetics

    PS -- If anyone sees any glaring factual errors, please shoot me a PM and let me know and I will change them ASAP.


    I will leave this thread open for any Q&A that folks might have to provide a continuing source for learning all in one place.
    -- Judy

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    Re: A Lesson in Basic Genetics


    -Lawrence

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    Re: A Lesson in Basic Genetics

    Wow..what a fantastic gift to the community

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    Re: A Lesson in Basic Genetics

    Quote Originally Posted by cueball
    Wow..what a fantastic gift to the community
    I don't think it could be said any better. And to think I had to go research all of that on my own when I learned it. There should be many grateful people sending you praise Judy. Thanks for this wonderful cointribution.
    Tim Bailey
    (A.K.A. MBM or Art Pimp)
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    The Blog

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    Re: A Lesson in Basic Genetics

    Judy this is a wonderful thing you've done for the people of this community, and I dont know what BP.Net would do without you!
    ~Dexter Mason~
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    I'm a firm believer in the philosophy of a ruling class. Especially since I rule. - Clerks
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    Randal Graves: Yes, but I love gatherings. Isn't it ironic?

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    Re: A Lesson in Basic Genetics

    Quote Originally Posted by muddoc
    I don't think it could be said any better. And to think I had to go research all of that on my own when I learned it. There should be many grateful people sending you praise Judy. Thanks for this wonderful cointribution.
    THIRDED!!!! Great, ez read.... GREAT WORK!!!!!! 's for Judy!!!!!
    Grey Scale is a good thing...

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    BPnet Veteran Holbeird's Avatar
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    Re: A Lesson in Basic Genetics

    vBulletin Message
    You must spread some Reputation around before giving it to JLC again.



    Bah humbug!
    ~Dexter Mason~
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    Re: A Lesson in Basic Genetics

    a MUCH needed stickie!!!!!


    Great Work Judy...
    -Kevin

  16. #10
    Don't Push My Buttons JLC's Avatar
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    Re: A Lesson in Basic Genetics

    Awww thanks, guys! I just hope someone learns something from it!


    JR...you can just go head and spread some around and then come back to this one. (I am SO kidding!!! ) Knowing you great folks think it is worthwhile is all the kudos I need!
    -- Judy

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