Well it's not big suprise the male refused after two such big meals. As for the female, it's not too suprising either. Any change in the environment can cause the fasting. I have had a couple girls stall out, so to speak, on their eating once they hit that size.
I'd work to try and get the humidity up, since that can cause problems like bad sheds. Try a bigger water bowl or just moving the current water bowl over the heat source.
On refreezing the rats, I will refreeze ONCE. If after the following week it get's trashed no matter what.