I try to feed all of my ball pythons once each week regardless if they are in shed or not. Some eat, some do not. I breed rats, so if they do not eat I just put the rat back in with the others until next week.

If the snake is in shed the chance of him / her eating is lowered. Some still eat though. If you are feeding live and have somewhere to keep the rat if it is not eaten, then go ahead and try. If you don't have somewhere to keep the rat, then don't attempt it. If you are feeding f/t, then go ahead and try.

Hope this helps.