I don't have a whole lot of experience with this stuff BUT... I would reiterate to watch out for weird smells. BP's are very attuned to scent. My 2 year old female, is an absolute sweetheart. The ONLY time she hissed and went into strike position was after I had come home from the doctor's office and reeked of "doctor smell". So maybe it is something that you are handling often that she is reacting to?