I'm sorry. I didn't mean to get anyone up in arms. I just meant in my experince 4 weeks tends to be too young. (and yes your experince far outstrips mine because I've only been breeding mice a year) But that's the point of these threads to share experinces.
I do not always wait a full 12 weeks with my mice.
Usually around 6 weeks they become breeders. I wean at 3-3.5 weeks depending on whether I've witnessed them eating solids. I agree keeping them with mom too long will wear her out. That's what grow out tubs are for.
I call 12 weeks a safe bet. Just as when we tell beginner bp keepers to have 2 hides but many sucessful keepers provide one or none. I'm telling beginners to give there young mice time to grow up until they are experinced enough to know what a healthy breeding weight is. (which I'm sorry to say I have no idea, I "eyeball" my mice, because I do not own a scale.)
Of course we want optimal health! we're feeding these animals to our pets. I never feed my snake a sickly mouse. I call anorexic a mouse half the weight it should be (though it is eating as much as it can so anorexic is the wrong word). I've only seen this 3 times in mice that came to me already prego, usually because they we're not seperated from there brothers at 4weeks. That's why I"m careful to wait for maturity. And yes I"m sure I have an 'inferior' strain of mice as most came from local pet stores. But I average 10per litter and have never had an act of canibalism.
That being said. I'm small time. Very small time. So good luck and I hope everyone finds a way that works for them.