Does your local water have a high chlorine concentration?

When I got my first ball he had a bad shed and despite misting and soaking it kept getting worse every time. I finally just stopped and it got better on it's own. I believe that the chlorine in the water was drying his skin out worse instead of helping.

You may want to try giving her a rest for a shed cycle to see if she takes care of herself. Or pay for bottled water for her soaks for a cycle to see if it makes a difference.