I use equine fresh and never spray the pellets (would defeat the purpose of maximum absorbency in my opinion)
Very little goes a long way, as the rodent urinate it will expend covering the bottom of the tub.
I clean once a week using this method.
As far as rats go I would highly recommend you to use a very small amount of pellets with wood shavings for nursing mother with pups under 2 weeks old.
When using pellets alone with pups under 2 weeks old I would loss about a third of my production due to suffocation.
Once the pups are 2 weeks old and over you can use pin pellets only.
For mice and ASF I use pine pellets at all time even for nursing mother.
Note: I have use pine pellets and pine shaving with all my rodents for the last 2 years without any ill effect.