I use equine fresh for about 90% of our rodent bedding, with some aspen for the nursing/birthing moms to nest in. I prefer it without spraying, especially in the male rat tubs, as they produce so much urine already, spraying the bedding means you have to change it more often. With mice, I find it doesnt make much of a difference.
The reason the spraying comes into effect is that the bedding is intended for horses, and spraying the pellets expands them, creating more volume and thus covering more space. This works well for horse stalls where you only have to fill it with say, 10 bags of sprayed pellets vs 15 unsprayed....much more cost effective, and since it is not cleaned entirely nearly as often as we do with rodent tubs, the loss of absorbance isnt as noticeable.
Hope this helps,
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