It has been my experience that readily available feeder rats are extremely poor quality and will need intensive concentration for generations to get to a stable, high producing rat that just doesn't crap out and die for no reason.
I have seen a young rat, clearly affected by the extreme bloating of megacolon in a feeder tank in my local pet store chain that buys from a large producer down in the south of the state.
That does not scream "hard culling". Most stores or producers put two animals together just to sell, and it's quite obvious in their feeders health and production.
That's why so many people come and ask that question, "Why did my feeder Breeder just die?", or "My Feeder rat only had 4 in a litter, is this normal?", "My rat came with mites! Help!"
Generally, we call them crap rats and that it will take some selective breeding on their part to get past the initial crap petstore feeder rats until they get large litters of healthy feeders.
Just my $0.2