That sucks!

This may be what you meant by having the fans set up the most advantageous way, so ignore my rambling if you've already done this. A lot of people make the mistake when using fans of having them all blowing air in from outside. You need to have approximately an equal amount blowing out as you do blowing in to keep the air moving.

If you have a multi-story house, you can cool it by having fans blowing IN on lower levels, and blowing OUT on the top level. Since the hot air rises, this gets the hottest air out of your house.

Another good trick is to blow in at windows that are in the shade, and out at windows that are in the sun. This often means reversing it halfway through the day.

If you know which direction the prevailing winds are blowing, set up the fans to blow the air in the same general direction the wind is blowing outside.