I would leave him alone for about a week and see if he calms down. Ball pythons are not problem handlers most of the time, and a week won't hurt anything.
How old is this ball python? He may be stressed out because of the amount of open space provided by the 40 gallon cage, especially if he is less than 2 years old.
You might want to get used to the idea that you own a snake, your probably going to get bitten once or twice. It's not painful, and it shouldn't really scare you that much.
Another idea if you can't reduce tank size, cover all but the front sides of the cage with black construction paper or something dark. Make sure to stuff his enclosure with fake plants and lots of decorations to make him feel more secure.
Just some ideas.
Also, you say he is hissing at nothing. This is probably not true, but rather he feels threatened that your standing in front of his cage, and that is what he's hissing at. He probably feels overexposed.![]()








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