Depends entirely on what species of "big female" she is. Two large rats a week might be fine for a really big boa or a growing burmese. But WAY too much food for any ball python. Regardless of species though...feeding more often than once a week for a mature snake is not usually recommended. Might be ok for babies and rapidly growing juvies...but for most commonly kept species, a mature snake never needs to eat more than every 7-10 days.