Joe you must be going nuts! When did you last see her?

Make sure there's a blanket or something stuffed under the door just in case she can squish out of the room that way. Start a search in one corner and fan outwards checking everything especially deep inside any closets, under dressers, between mattresses, etc. If you figure there's no way a snake could get in there....check that place first!

If it gives you hope, we had one of our female snakes disappear on us. Out of a locked tub, out of a secure snake room. One little clip is all it took that wasn't quite clipped on right and she was gone. How she got out of that room I'm not sure. Either she got under the door or snuck out when the room was open during cleaning/feeding.

We found her, Joe, or rather she found us. On another floor of the house in a room (our master bedroom) where the door is shut 95% of the time. One day, out of the blue, there she was. Knocked over a stack of paperbacks and was parked on top like she was wondering when we'd finally get around to finding her. Not a mark on her, not much weight loss, not even acting stressed at all.....basically just a bit thirsty. She'd been missing 4 months.

Don't give up hope and keep looking. Also if you don't find her right away watch for evidence like urates, sheds, things moved out of place, that might indicate where she's at.