If he has not been exposed to any other snakes (especially boas) in the last month or two, you can rule out IBD as a scare. IBD kills pythons, usually within 30 days of exposure. It is a swift killer of pythons.

Has anything changed in his enclosure or location recently? Constant roaming around signals to me that my snakes are stressed out (if it's not the normal late night roaming) and I work to reduce the stress by reducing my handling to almost nothing, as well as filling the enclosure with loosely crumpled newspaper, so that the snake can feel things touching it on all sides, which helps to settle them down (a Kevin McCurley tip that's been used by many keepers here).