Mike, just set up simple routines and habits with her. Don't let her attitude be the defining thing or set the tone for how you interact with her. Find something, whether that's a tap on the nose or a spritz of cool water, that sets her back long enough to get a good hold of her then just go for it. Keep her under control until she gets it through her small snake brain that acting up isn't getting the desired results. Just be calm, controlled, firm but gentle and most of all very consistent with her. Small routines done over and over with these snakes seem to help them understand that when A happens then B will occur next and they aren't going to be harmed or preyed upon. Once they get this, most do seem to calm down and stop being as defensive.

If she's being a real turd about stuff, put on some gloves but just don't let her get into the habit of running the show by snapping at you. Some of them are snappy but most ball pythons are pretty laid back. They are snakes though and will school you occasionally. We have a breeder female here that tends to be a snake that will "remind" you if you aren't mindful of her and she nailed my husband last week but good. Nothing different, nothing new, nothing to really trigger a bite but she did it anyways - it happens - you clean up the blood drops and move on.