Feeding girth-sized prey items to adult blood pythons on a frequent basis makes about as much sense as running a Honda Accord on racing fuel for every day use.
To echo what's already been said, bloods & STP's do have very slow metabolisms, especially as adult animals. They also tend to have TREMENDOUS feeding responses & will eat just about any time you try to offer them food. This is where the whole "just because you can, doesn't mean you should or that it's healthy" thing comes into play.
Even my very biggest girls get medium (and very occasionally, a large here or there) rats every 10-14 days or so, and these are genuine 6'+ females that average 25 lbs, and are anywhere from 7-13 years of age.
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