Balling up tightly when handled and refusing to unball.
Frantically trying to escape while being handled.
Striking when no food or food-scents are present.
Refusal to eat (rule out shedding or breeding-cycle fasts)
Constant motion within its enclosure.
Always trying to escape its enclosure.
Striking at food and/or killing it but not eating.
Some signs of stress I always look for in my ball pythons are:
Always squeezing one of those stress dolls where the head looks like it's going to pop.
A lot of pacing and muttering to him/herself.
Becomes quite irate when dinner isn't done on time.
Always worried they're going to lose the big contract at work and won't make partner.
Breathing heavily in and out of a paper bag.
Resorting to alcohol or recreational drug use.
"If I were stranded on a desert island and could only have one book, record and person...I'd probably die of exposure."
Lol! Yeah, that sounds like a stressed out snake to me!
If your snake balls up tightly and hisses or "puffs" at you every time you reach for it.
If you are struck at often.
If he slithers constantly around his enclosure "testing" possible areas of escape (not to be confused with resting against the glass to warm up).
You will probably know when he's not happy.
Stand up for what's right, even if you're standing alone. I'm clearly the only crazy person here