Possible signs of stress:
Balling up tightly when handled and refusing to unball.
Frantically trying to escape while being handled.
Striking when no food or food-scents are present.
Refusal to eat (rule out shedding or breeding-cycle fasts)
Constant motion within its enclosure.
Always trying to escape its enclosure.
Striking at food and/or killing it but not eating.
Those are several that spring to mind.
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