Diluted bleach will do a great job, but just remember to rinse VERY well. I clean my enclosure right out/full wash once a month. But I change the water daily, and the substrate whenever it is soiled. I use Scott Shop Towels, so it is MUCH easier for me to see urine/urates/poop immediately and clean it up. When I was using cypress mulch, I cleaned the tank right out every 2 weeks or so since the substrate needed to be changed that often anyway.