I've never chosen to by from a 'large' breeder though I have inquired on animals at NERD a few times.
I did have an experience with a larger breeder though. I'd inquired about some animals of theirs and while they did respond and were polite over a month later I still had no information or pictures so I gave up. I've seen people successfully get photos and animals from them after this but honestly I probably won't attempt to purchase from them again.
I am not truly picky but after thinking back most of my animals have been purchased from small breeders. Adam is probably the largest I've purchased from.