We normally wait 48 hours for handling. That's handling though - actually getting the snake out to muck about with it. If I check the snakes and somebody's made a huge mess of their tub right after feeding, I might gently move the snake in order to make sure they have a clean environment. I'm careful, I'm gentle and I get in and out of their fast. That usually doesn't bother them at all but is not the same thing as a full on handling experience.