Yes, mice don't like to have intruders invading their homes. I've found it difficult to even set up breeding groups once they get too old. Once I've got a breeding group together, they stay together for their entire lives and eventually retire together. Mice are very jumpy and don't take well to change. I've found that the best way to raise mice is to put them in a dark out of the way place and ignore them as much as possible. Mice hate being watched, they really want to remain hidden.
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