Well Hammer I think I noticed in your other posts that you mentioned a few relevent points. You've had this snake since Monday, so less than one week at this point. You are fiddling about with it's enclosure, changing things up. You are handling this snake and letting it loose from your direct control.

The issues here are that you are most likely stressing this snake out completely. You need to think like a snake for a moment here, Hammer. This snake is new to your home, possibly quite young, hasn't been allowed to properly settle in and it's environment is changing. When you put it on the floor and stand over it, it's seeing you as a big heat emitting predator so of course it dashes for safety or it's out in the open where any predator could find it so it seeks a hidden place...that's normal snake behaviour. Ball pythons are snakes that live mostly underground in burrows and tunnels...they don't do open spaces all that well.

Hissing and striking at you are defensive behaviours because it's stressed, doesn't have the ability to understand the changes in it's life and if it's home is not set up properly...it just plain doesn't feel right. You need to focus on setting up it's home properly for a ball python, stop the handling for now and just get it settled and feeding regularily. Handling will come when the snake is more able to accept it. That handling should be done slowly with respect for what your snake is and what it isn't capable of dealing with.