My male albino is still a little guy and he hisses any time I open his tank, but as soon as I get him in my hands hes fine. My male normal that is about 750 grams only hisses when he is in shed and really doesn't want to be messed up. I did have a little female that was demon snake, she snapped all the time and hissed at anything...but I think that was due to the fact she learned as soon as the lid on the tank came off and i took out her tree, it was feeding time, she would snap at the air just to be snapping.